Indiana University Purdue University Indianpolis - IUPUI
Location: Bloomington, Indiana
Internal Number: 11951
Location: IU School of Medicine
Department: IUSM - Medicine - Clinical Pharmacology
Campus: IU School of Medicine Indianapolis
The Department of Medicine, Division of Clinical Pharmacology, in collaboration with the Stark Neurosciences Research Institute (SNRI) at Indiana University School of Medicine (IUSM), Indianapolis, Indiana is seeking a qualified candidate to join our investigative cellular pharmacology lab of the Alzheimer's Disease Drug Discovery Center. This position is for a full-time postdoctoral fellow which will allow the successful candidate the opportunity to gain experience in preparing for a career in drug discovery research.
The primary responsibilities of this postdoctoral fellow will be:
Generation of hypothesis for target identification and validation. Design and perform cell-based assays testing drug molecules in vitro activities with methods such as western blot for proteins, ELISA, and other homogeneous cell assays with plate reader, flow cytometry, cellular imaging, immunocytochemistry, histology, detection of molecular interactions such as protein-protein or drug-protein interactions, extraction, and measurement of cellular mRNA, PCR methods.
Maintain cell cultures to ensure the cellular pharmacology experiments needs including setting up and maintaining cell cultures, passage cells, freezing and stocking cell lines, and reviving frozen cells. Experiments will use various cell lines, iPSC, and primary cells.
Establish cellular models for in vitro studies. Experiences on transient and stable transfection of cells for protein expression and cell cloning. Experience with gene knockout and editing with siRNA or CRISPR-Cas9 methods are helpful.
Skills in data analysis with software including basic statistical analysis.
Opportunities to write manuscripts for publication, and develop and submit grant proposals for career development.
Excellent communication skills with proficiency in written and verbal English.
Must work well both independently and as a team player. Experience with laboratory management skills, as well as mentoring junior researchers and students is also desirable.
About the School and Department: The Indiana University School of Medicine https://medicine.iu.edu/ is the largest medical school in the US and is annually ranked among the top medical schools in the US by US News & World Report. Please visit http://medicine.iupui.edu for additional information about the Department of Medicine.
About the Campus: To learn more about the Indiana University-Purdue University Indianapolis campus, please visit: http://www.iupui.edu/about/
Indianapolis is the capital and most populous city in the State of Indiana. It is growing economically thanks to a strong corporate base anchored by the life sciences. Indiana is home to one of the largest concentrations of health sciences companies in the nation. Indianapolis has a sophisticated blend of charm and culture with a wonderful balance of business and leisure. The growing residential base is supported by rich amenities and quality of life – the city possesses a variety of professional sports, arts venues, and outdoor recreation areas. Residents of this dynamic city, and surrounding suburbs, enjoy leading educational systems and top-ranked universities, paired with a diverse population. Indianapolis International Airport is a top-ranked international airport, being named
About Indiana University Purdue University Indianpolis - IUPUI
Founded in 1820, Indiana University is the state’s public university system, comprised of two core campuses—IU-Bloomington and IUPUI—and six regional campuses located throughout the state. Combined, the total student population is more than 114,000 undergraduate, graduate and professional school students. IU is one of the largest employers in the state, with over 20,000 faculty and staff. Indiana University is an equal employment and affirmative action employer and a provider of ADA services. Diversity and inclusion remains a core commitment to IU’s mission to cultivate an educational environment that supports equal access, participation and representation on all of its campuses and that provides educational and career opportunities for all.