This is an entry-level Research Technician position within the Department of Biochemistry and Molecular Biology at the IU School of Medicine (Indianapolis campus). The Research Technician will interact with a collaborative group of researchers studying cancer, infectious diseases, and glycogen storage diseases.
J ob Duties/Responsibilities:
Primary responsibilities will be to synthesize organic molecules and evaluate their bioactivities in a panel of biochemical and cell-based assays to develop structure-activity relationships and elucidate inhibitor mechanisms of action. Requires skills in chemical synthesis, purification, and analysis by HPLC, NMR, and LC-MS; assay development and compound screening; bacterial and mammalian cell culture; and protein expression and purification.
Perform general duties to ensure the lab operates safely and efficiently, including: - assisting the PI with monitoring the completion of assigned tasks. - ordering supplies/equipment and obtaining product quotes. - maintaining equipment, reagents, databases, and coordinating waste disposal. - serving as a resource to lab personnel.
- Maintain knowledge of scientific trends through readings and seminars. - Review literature to identify suitable procedures and methods.
Preparation of Research Reports & Presentations:
- Assist in preparing and submitting project reports, manuscripts, and grants.
Note: This entry-level position will be well-suited for individuals who have recently received their BSc or MSc.
Bachelor's degree in science and practical synthetic organic, medicinal, and analytical chemistry experience in a research setting.
Synthetic organic, medicinal, and analytical chemistry skills. Retrosynthetic analysis to develop procedures for synthesizing target compounds. Ability to synthesize compounds from mg to g scale using inert atmosphere techniques, and purification via normal- and reverse-phase chromatography. Ability to analyze and characterize compounds by RP-HPLC, LC-MS, and proton/carbon NMR. Excellent organizational skills and independent scientific problem solving abilities. Ability to adhere to chemical and biological safety practices within a laboratory research setting. Excellent communication skills and ability to work well with others.
Areas of study in organic/medicinal chemistry, biochemistry, chemical biology, molecular biology, cell biology, or a related field. Enzymatic and cell-based assay development, compound screening, and molecular and cell biology and biochemistry experience. Knowledge of evaluating compounds in enzymatic and cell-based assays (including radioactivity-based detection), protein expression and purification, and bacterial and mammalian cell culture. Experience with software including ChemDraw, ChemFinder, MestReNova, CLC Sequence Viewer, Discovery Studio, SoftMax Pro, Waters Empower 3, GraphPad Prism, SciFinder Scholar, Microsoft Windows and Office (Word, Excel, PowerPoint), and EndNote.
Working Conditions / Demands
Must be able to perform essential functions of the postition with or without an accommodation.
Equipment utilized: General research lab equipment including balances, fumehoods, fridges, freezers, pH meters, centrifuges, incubators, shakers, pipets, etc. More specialized equipment for chemistry duties includes rotovaps, Biotage Isolera flash chromatography systems, Biotage microwave synthesizers, HPLCs (analytical and preparatory), lyophilizers, NMRs, and LC-Mass Specs. Additional equipment includes autoclaves, biosafety hoods, microplate dispensers and readers, thermocyclers, and FPLCs.
Salary Plan: RS
Salary Grade: 07
Job Function: Research
Due to the COVID-19 pandemic, there may be differences in the working conditions as advertised in our standard job postings (e.g., the ability to travel from one campus to another, etc.). If you are invited for an interview, please discuss your questions or concerns regarding the working conditions at that time.
This posting is scheduled to close at 11:59 pm EST on the advertised Close Date. This posting may be closed at any time at the discretion of the University, but will remain open for a minimum of 5 business days. To guarantee full consideration, please submit your application within 5 business days of the Posted Date.
If you wish to include a cover letter, you may include it with your resume when uploading attachments.
Equal Employment Opportunity
Indiana University is an equal employment and affirmative action employer and a provider of ADA services. All qualified applicants will receive consideration for employment without regard to age, ethnicity, color, race, religion, sex, sexual orientation, gender identity or expression, genetic information, marital status, national origin, disability status or protected veteran status. Indiana University does not discriminate on the basis of sex in its educational programs and activities, including employment and admission, as required by Title IX. Questions or complaints regarding Title IX may be referred to the U.S. Department of Education Office for Civil Rights or the university Title IX Coordinator. See Indiana University's Notice of Non-Discrimination here which includes contact information .
Campus Safety and Security
The Annual Security and Fire Safety Report, containing policy statements, crime and fire statistics for all Indiana University campuses, is available online . You may also request a physical copy by emailing IU Public Safety at firstname.lastname@example.org or by visiting IUPD.
Founded in 1820, Indiana University is the state’s public university system, comprised of two core campuses—IU-Bloomington and IUPUI—and six regional campuses located throughout the state. Combined, the total student population is more than 114,000 undergraduate, graduate and professional school students. IU is one of the largest employers in the state, with over 20,000 faculty and staff. Indiana University is an equal employment and affirmative action employer and a provider of ADA services. Diversity and inclusion remains a core commitment to IU’s mission to cultivate an educational environment that supports equal access, participation and representation on all of its campuses and that provides educational and career opportunities for all.